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The role of wild type RAS isoforms in cancer

Mutationally activated RAS proteins are critical oncogenic drivers in nearly 30% of all human cancers. As with mutant RAS, the role of wild type RAS proteins in oncogenesis, tumour maintenance and metastasis is context-dependent. Complexity is introduced by the existence of multiple RAS genes (HRAS,...

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Bibliografiske detaljer
Udgivet i:Semin Cell Dev Biol
Main Authors: Zhou, Bingying, Der, Channing J., Cox, Adrienne D.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5028303/
https://ncbi.nlm.nih.gov/pubmed/27422332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.semcdb.2016.07.012
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