Multiplexed, targeted profiling of single-cell proteomes and transcriptomes in a single reaction

We present a scalable, integrated strategy for coupled protein and RNA detection from single cells. Our approach leverages the DNA polymerase activity of reverse transcriptase to simultaneously perform proximity extension assays and complementary DNA synthesis in the same reaction. Using the Fluidig...

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Bibliografiske detaljer
Udgivet i:Genome Biol
Main Authors: Genshaft, Alex S, Li, Shuqiang, Gallant, Caroline J., Darmanis, Spyros, Prakadan, Sanjay M., Ziegler, Carly G. K., Lundberg, Martin, Fredriksson, Simon, Hong, Joyce, Regev, Aviv, Livak, Kenneth J., Landegren, Ulf, Shalek, Alex K.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2016
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Method
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5027636/
https://ncbi.nlm.nih.gov/pubmed/27640647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-016-1045-6
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