Profiling of 2′-O-Me in human rRNA reveals a subset of fractionally modified positions and provides evidence for ribosome heterogeneity

Ribose methylation is one of the two most abundant modifications in human ribosomal RNA and is believed to be important for ribosome biogenesis, mRNA selectivity and translational fidelity. We have applied RiboMeth-seq to rRNA from HeLa cells for ribosome-wide, quantitative mapping of 2′-O-Me sites...

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Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Krogh, Nicolai, Jansson, Martin D., Häfner, Sophia J., Tehler, Disa, Birkedal, Ulf, Christensen-Dalsgaard, Mikkel, Lund, Anders H., Nielsen, Henrik
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2016
Sujets:
RNA
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5027482/
https://ncbi.nlm.nih.gov/pubmed/27257078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw482
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