Profiling of 2′-O-Me in human rRNA reveals a subset of fractionally modified positions and provides evidence for ribosome heterogeneity

Ribose methylation is one of the two most abundant modifications in human ribosomal RNA and is believed to be important for ribosome biogenesis, mRNA selectivity and translational fidelity. We have applied RiboMeth-seq to rRNA from HeLa cells for ribosome-wide, quantitative mapping of 2′-O-Me sites...

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Bibliographische Detailangaben
Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Krogh, Nicolai, Jansson, Martin D., Häfner, Sophia J., Tehler, Disa, Birkedal, Ulf, Christensen-Dalsgaard, Mikkel, Lund, Anders H., Nielsen, Henrik
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2016
Schlagworte:
RNA
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5027482/
https://ncbi.nlm.nih.gov/pubmed/27257078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw482
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