Profiling of 2′-O-Me in human rRNA reveals a subset of fractionally modified positions and provides evidence for ribosome heterogeneity

Ribose methylation is one of the two most abundant modifications in human ribosomal RNA and is believed to be important for ribosome biogenesis, mRNA selectivity and translational fidelity. We have applied RiboMeth-seq to rRNA from HeLa cells for ribosome-wide, quantitative mapping of 2′-O-Me sites...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Krogh, Nicolai, Jansson, Martin D., Häfner, Sophia J., Tehler, Disa, Birkedal, Ulf, Christensen-Dalsgaard, Mikkel, Lund, Anders H., Nielsen, Henrik
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5027482/
https://ncbi.nlm.nih.gov/pubmed/27257078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw482
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