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Profiling of ribose methylations in ribosomal RNA from diffuse large B-cell lymphoma patients for evaluation of ribosomes as drug targets
Cancer cells are addicted to ribosome biogenesis and high levels of translation. Thus, differential inhibition of cancer cells can be achieved by targeting aspects of ribosome biogenesis or ribosome function. Using RiboMeth-seq for profiling of the ∼112 2′-O-Me sites in human ribosomal RNA, we demon...
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| Pubblicato in: | NAR Cancer |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8210301/ https://ncbi.nlm.nih.gov/pubmed/34316692 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/narcan/zcaa035 |
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