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Interplay between hydrophobicity and the positive-inside rule in determining membrane-protein topology

The energetics of membrane-protein interactions determine protein topology and structure: hydrophobicity drives the insertion of helical segments into the membrane, and positive charges orient the protein with respect to the membrane plane according to the positive-inside rule. Until recently, howev...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Elazar, Assaf, Weinstein, Jonathan Jacob, Prilusky, Jaime, Fleishman, Sarel Jacob
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5027447/
https://ncbi.nlm.nih.gov/pubmed/27562165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1605888113
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