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Mutational scanning reveals the determinants of protein insertion and association energetics in the plasma membrane

Insertion of helix-forming segments into the membrane and their association determines the structure, function, and expression levels of all plasma membrane proteins. However, systematic and reliable quantification of membrane-protein energetics has been challenging. We developed a deep mutational s...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Elazar, Assaf, Weinstein, Jonathan, Biran, Ido, Fridman, Yearit, Bibi, Eitan, Fleishman, Sarel Jacob
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4786438/
https://ncbi.nlm.nih.gov/pubmed/26824389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.12125
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