Zinc-sensitive MRI contrast agent detects differential release of Zn(II) ions from the healthy vs. malignant mouse prostate

Many secretory tissues release Zn(II) ions along with other molecules in response to external stimuli. Here we demonstrate that secretion of Zn(II) ions from normal, healthy prostate tissue is stimulated by glucose in fasted mice and that release of Zn(II) can be monitored by MRI. An ∼50% increase i...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Clavijo Jordan, M. Veronica, Lo, Su-Tang, Chen, Shiuhwei, Preihs, Christian, Chirayil, Sara, Zhang, Shanrong, Kapur, Payal, Li, Wen-Hong, De Leon-Rodriguez, Luis M., Lubag, Angelo J. M., Rofsky, Neil M., Sherry, A. Dean
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5027418/
https://ncbi.nlm.nih.gov/pubmed/27562169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1609450113
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