Treatment with didemnin B, an elongation factor 1A inhibitor, improves hepatic lipotoxicity in obese mice

Eukaryotic elongation factor EEF1A1 is induced by oxidative and ER stress, and contributes to subsequent cell death in many cell types, including hepatocytes. We recently showed that blocking the protein synthesis activity of EEF1A1 with the peptide inhibitor, didemnin B, decreases saturated fatty a...

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Veröffentlicht in:Physiol Rep
Hauptverfasser: Hetherington, Alexandra M., Sawyez, Cynthia G., Sutherland, Brian G., Robson, Debra L., Arya, Rigya, Kelly, Karen, Jacobs, René L., Borradaile, Nica M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2016
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5027364/
https://ncbi.nlm.nih.gov/pubmed/27613825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.12963
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