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Treatment with didemnin B, an elongation factor 1A inhibitor, improves hepatic lipotoxicity in obese mice

Eukaryotic elongation factor EEF1A1 is induced by oxidative and ER stress, and contributes to subsequent cell death in many cell types, including hepatocytes. We recently showed that blocking the protein synthesis activity of EEF1A1 with the peptide inhibitor, didemnin B, decreases saturated fatty a...

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Detalhes bibliográficos
Publicado no:Physiol Rep
Main Authors: Hetherington, Alexandra M., Sawyez, Cynthia G., Sutherland, Brian G., Robson, Debra L., Arya, Rigya, Kelly, Karen, Jacobs, René L., Borradaile, Nica M.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5027364/
https://ncbi.nlm.nih.gov/pubmed/27613825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.12963
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