Treatment with didemnin B, an elongation factor 1A inhibitor, improves hepatic lipotoxicity in obese mice

Eukaryotic elongation factor EEF1A1 is induced by oxidative and ER stress, and contributes to subsequent cell death in many cell types, including hepatocytes. We recently showed that blocking the protein synthesis activity of EEF1A1 with the peptide inhibitor, didemnin B, decreases saturated fatty a...

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Foilsithe in:Physiol Rep
Main Authors: Hetherington, Alexandra M., Sawyez, Cynthia G., Sutherland, Brian G., Robson, Debra L., Arya, Rigya, Kelly, Karen, Jacobs, René L., Borradaile, Nica M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: John Wiley and Sons Inc. 2016
Ábhair:
Original Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5027364/
https://ncbi.nlm.nih.gov/pubmed/27613825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.12963
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