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A FRET biosensor reveals spatiotemporal activation and functions of aurora kinase A in living cells
Overexpression of AURKA is a major hallmark of epithelial cancers. It encodes the multifunctional serine/threonine kinase aurora A, which is activated at metaphase and is required for cell cycle progression; assessing its activation in living cells is mandatory for next-generation drug design. We de...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5027284/ https://ncbi.nlm.nih.gov/pubmed/27624869 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12674 |
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