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Structure of inositol monophosphatase, the putative target of lithium therapy.

Inositol monophosphatase (EC 3.1.3.25), the putative molecular site of action of lithium therapy for manic-depressive illness, plays a key role in the phosphatidylinositol signaling pathway by catalyzing the hydrolysis of inositol monophosphates. To provide a structural basis from which to design be...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Bone, R, Springer, J P, Atack, J R
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1992
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC50271/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1332026/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.21.10031
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