Acute Catecholamine Exposure Causes Reversible Myocyte Injury Without Cardiac Regeneration

RATIONALE: Catecholamines increase cardiac contractility, but exposure to high concentrations or prolonged exposures can cause cardiac injury. A recent study demonstrated that a single subcutaneous injection of isoproterenol (ISO; 200 mg/kg) in mice causes acute myocyte death (8-10%) with complete c...

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Vydáno v:Circ Res
Hlavní autoři: Wallner, Markus, Duran, Jason M., Mohsin, Sadia, Troupes, Constantine D., Vanhoutte, Davy, Borghetti, Giulia, Vagnozzi, Ronald J, Gross, Polina, Yu, Daohai, Trappanese, Danielle M., Kubo, Hajime, Toib, Amir, Sharp, Thomas E., Harper, Shavonn C., Volkert, Michael A., Starosta, Timothy, Feldsott, Eric A., Berretta, Remus M., Wang, Tao, Barbe, Mary F., Molkentin, Jeffrey D., Houser, Steven R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5026617/
https://ncbi.nlm.nih.gov/pubmed/27461939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.116.308687
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