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A synthetic cell-penetrating dominant-negative ATF5 peptide exerts anti-cancer activity against a broad spectrum of treatment resistant cancers

PURPOSE: Despite significant progress in cancer research many tumor entities still have an unfavorable prognosis. Activating Transcription Factor 5 (ATF5) is up-regulated in various malignancies and promotes apoptotic resistance. We evaluated the efficacy and mechanisms of the first described synthe...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Karpel-Massler, Georg, Horst, Basil A., Shu, Chang, Chau, Lily, Tsujiuchi, Takashi, Bruce, Jeffrey N., Canoll, Peter, Greene, Lloyd A., Angelastro, James M., Siegelin, Markus D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5026557/
https://ncbi.nlm.nih.gov/pubmed/27126996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-2827
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