WRN promoter CpG island hypermethylation does not predict more favorable outcomes for metastatic colorectal cancer patients treated with irinotecan-based therapy

PURPOSE: WRN promoter CpG island hypermethylation in colorectal cancer (CRC) has been reported to increase sensitivity to irinotecan-based therapies. We aimed to characterize methylation of the WRN promoter; determine the effect of WRN promoter hypermethylation upon expression; and validate a previo...

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Publicado no:Clin Cancer Res
Main Authors: Bosch, Linda J.W., Luo, Yanxin, Lao, Victoria Valinluck, Snaebjornsson, Petur, Trooskens, Geert, Vlassenbroeck, Ilse, Mongera, Sandra, Tang, Weiliang, Welcsh, Piri, Herman, James G, Koopman, Miriam, Nagtegaal, Iris D., Punt, Cornelis JA, van Criekinge, Wim, Meijer, Gerrit A., Monnat, Raymond J., Carvalho, Beatriz, Grady, William M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5026547/
https://ncbi.nlm.nih.gov/pubmed/27121793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-2703
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