WRN promoter CpG island hypermethylation does not predict more favorable outcomes for metastatic colorectal cancer patients treated with irinotecan-based therapy

PURPOSE: WRN promoter CpG island hypermethylation in colorectal cancer (CRC) has been reported to increase sensitivity to irinotecan-based therapies. We aimed to characterize methylation of the WRN promoter; determine the effect of WRN promoter hypermethylation upon expression; and validate a previo...

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Pubblicato in:Clin Cancer Res
Autori principali: Bosch, Linda J.W., Luo, Yanxin, Lao, Victoria Valinluck, Snaebjornsson, Petur, Trooskens, Geert, Vlassenbroeck, Ilse, Mongera, Sandra, Tang, Weiliang, Welcsh, Piri, Herman, James G, Koopman, Miriam, Nagtegaal, Iris D., Punt, Cornelis JA, van Criekinge, Wim, Meijer, Gerrit A., Monnat, Raymond J., Carvalho, Beatriz, Grady, William M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5026547/
https://ncbi.nlm.nih.gov/pubmed/27121793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-2703
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