Divergent Ah Receptor Ligand Selectivity during Hominin Evolution

We have identified a fixed nonsynonymous sequence difference between humans (Val381; derived variant) and Neandertals (Ala381; ancestral variant) in the ligand-binding domain of the aryl hydrocarbon receptor (AHR) gene. In an exome sequence analysis of four Neandertal and Denisovan individuals compa...

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Publicado en:Mol Biol Evol
Autores principales: Hubbard, Troy D., Murray, Iain A., Bisson, William H., Sullivan, Alexis P., Sebastian, Aswathy, Perry, George H., Jablonski, Nina G., Perdew, Gary H.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2016
Materias:
Discoveries
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5026259/
https://ncbi.nlm.nih.gov/pubmed/27486223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msw143
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