Phenotypic similarities between late-onset autosomal dominant and sporadic Alzheimer disease: A single-family case-control study

IMPORTANCE: The “amyloid hypothesis” posits that disrupted amyloid-beta (Aβ) homeostasis initiates the pathological process resulting in Alzheimer disease (AD). Autosomal dominant Alzheimer disease (ADAD) has an early symptomatic onset and is caused by single gene mutations that result in overproduc...

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Publicado en:JAMA Neurol
Autores principales: Day, Gregory S, Musiek, Erik S, Roe, Catherine M, Norton, Joanne, Goate, Alison M, Cruchaga, Carlos, Cairns, Nigel J, Morris, John C
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5025942/
https://ncbi.nlm.nih.gov/pubmed/27454811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaneurol.2016.1236
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