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A Novel Assay for Screening Inhibitors Targeting HIV Integrase LEDGF/p75 Interaction Based on Ni(2+) Coated Magnetic Agarose Beads

HIV-1 integrase (IN) plays an essential role in viral replication and thus serves as an important target for chemotherapeutic intervention against HIV-1 infection. However, the current three clinical IN inhibitors, raltegravir, elvitegravir and dolutegravir share the same inhibitory mechanism, resul...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Dawei, Zhang, Hongqiu, He, Mengmeng, Liu, Zhixia, Meng, Shunxing, Guo
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5025856/
https://ncbi.nlm.nih.gov/pubmed/27633629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep33477
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