The selenium-containing drug ebselen potently disrupts LEDGF/p75-HIV-1 integrase interaction by targeting LEDGF/p75

Lens-epithelium-derived growth-factor (LEDGF/p75)-binding site on HIV-1 integrase (IN), is an attractive target for antiviral chemotherapy. Small-molecule compounds binding to this site are referred as LEDGF-IN inhibitors (LEDGINs). In this study, compound libraries were screened to identify new inh...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Enzyme Inhib Med Chem
Egile Nagusiak: Zhang, Da-Wei, Yan, Hao-Li, Xu, Xiao-Shuang, Xu, Lei, Yin, Zhi-Hui, Chang, Shan, Luo, Heng
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Taylor & Francis 2020
Gaiak:
Research Paper
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7170385/
https://ncbi.nlm.nih.gov/pubmed/32228103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2020.1743282
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