Therapeutic drug monitoring, electronic health records, and pharmacokinetic modeling to evaluate sirolimus drug exposure-response relationships in renal transplant patients

BACKGROUND: Sirolimus, an immunosuppressant agent used in renal transplantation, can prevent allograft rejection. Identification of the therapeutic index (ratio of minimum toxic concentration to minimum therapeutic concentration) for immunosuppresants is necessary to optimize the care of patients an...

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Dettagli Bibliografici
Pubblicato in:Ther Drug Monit
Autori principali: Zimmerman, Kanecia O., Wu, Huali, Greenberg, Rachel, Hill, Kevin, Patel, Uptal D., Ku, Lawrence, Gonzalez, Daniel, Hornik, Christoph, Jiang, Wenlei, Zheng, Nan, Melloni, Chiara, Cohen-Wolkowiez, Michael
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5025355/
https://ncbi.nlm.nih.gov/pubmed/27259059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FTD.0000000000000313
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