Therapeutic drug monitoring, electronic health records, and pharmacokinetic modeling to evaluate sirolimus drug exposure-response relationships in renal transplant patients

BACKGROUND: Sirolimus, an immunosuppressant agent used in renal transplantation, can prevent allograft rejection. Identification of the therapeutic index (ratio of minimum toxic concentration to minimum therapeutic concentration) for immunosuppresants is necessary to optimize the care of patients an...

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Udgivet i:Ther Drug Monit
Main Authors: Zimmerman, Kanecia O., Wu, Huali, Greenberg, Rachel, Hill, Kevin, Patel, Uptal D., Ku, Lawrence, Gonzalez, Daniel, Hornik, Christoph, Jiang, Wenlei, Zheng, Nan, Melloni, Chiara, Cohen-Wolkowiez, Michael
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5025355/
https://ncbi.nlm.nih.gov/pubmed/27259059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FTD.0000000000000313
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