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Werner Syndrome: Clinical Features, Pathogenesis and Potential Therapeutic Interventions

Werner syndrome (WS) is a prototypical segmental progeroid syndrome characterized by multiple features consistent with accelerated aging. It is caused by null mutations of the WRN gene, which encodes a member of the RECQ family of DNA helicases. A unique feature of the WRN helicase is the presence o...

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Detalhes bibliográficos
Publicado no:Ageing Res Rev
Main Authors: Oshima, Junko, Sidorova, Julia M., Monnat, Raymond J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5025328/
https://ncbi.nlm.nih.gov/pubmed/26993153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.arr.2016.03.002
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