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A Rational Engineering Strategy for Designing Protein A-Binding Camelid Single-Domain Antibodies
Staphylococcal protein A (SpA) and streptococcal protein G (SpG) affinity chromatography are the gold standards for purifying monoclonal antibodies (mAbs) in therapeutic applications. However, camelid V(H)H single-domain Abs (sdAbs or V(H)Hs) are not bound by SpG and only sporadically bound by SpA....
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| Publicado no: | PLoS One |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5025174/ https://ncbi.nlm.nih.gov/pubmed/27631624 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0163113 |
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