KDM4A coactivates E2F1 to regulate PDK-dependent metabolic switch between mitochondrial oxidation and glycolysis

The histone lysine demethylase KDM4A/JMJD2A has been implicated in prostate carcinogenesis through its role in transcriptional regulation. Here, we describe KDM4A as a E2F1 coactivator and demonstrate a functional role for the E2F1-KDM4A complex in the control of tumor metabolism. KDM4A associates w...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell Rep
Egile Nagusiak: Wang, Ling-Yu, Hung, Chiu-Lien, Chen, Yun-Ru, Yang, Joy C., Wang, Junjian, Campbell, Mel, Izumiya, Yoshihiro, Chen, Hong-Wu, Wang, Wen-Ching, Ann, David K., Kung, Hsing-Jien
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2016
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5024724/
https://ncbi.nlm.nih.gov/pubmed/27626669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.08.018
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak