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Reprogramming the local lymph node microenvironment promotes tolerance that is systemic and antigen-specific
Many experimental therapies for autoimmune diseases, such as multiple sclerosis (MS), aim to bias T cells towards tolerogenic phenotypes without broad suppression. However, the link between local signal integration in lymph nodes (LNs) and the specificity of systemic tolerance is not well understood...
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| Publicado en: | Cell Rep |
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| Autores principales: | , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5024722/ https://ncbi.nlm.nih.gov/pubmed/27626664 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.08.033 |
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