Reprogramming the local lymph node microenvironment promotes tolerance that is systemic and antigen-specific

Many experimental therapies for autoimmune diseases, such as multiple sclerosis (MS), aim to bias T cells towards tolerogenic phenotypes without broad suppression. However, the link between local signal integration in lymph nodes (LNs) and the specificity of systemic tolerance is not well understood...

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Udgivet i:Cell Rep
Main Authors: Tostanoski, Lisa H., Chiu, Yu-Chieh, Gammon, Joshua M., Simon, Thomas, Andorko, James I., Bromberg, Jonathan S., Jewell, Christopher M.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5024722/
https://ncbi.nlm.nih.gov/pubmed/27626664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.08.033
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