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Reprogramming the local lymph node microenvironment promotes tolerance that is systemic and antigen-specific

Many experimental therapies for autoimmune diseases, such as multiple sclerosis (MS), aim to bias T cells towards tolerogenic phenotypes without broad suppression. However, the link between local signal integration in lymph nodes (LNs) and the specificity of systemic tolerance is not well understood...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Rep
Prif Awduron: Tostanoski, Lisa H., Chiu, Yu-Chieh, Gammon, Joshua M., Simon, Thomas, Andorko, James I., Bromberg, Jonathan S., Jewell, Christopher M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5024722/
https://ncbi.nlm.nih.gov/pubmed/27626664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.08.033
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