Lineage-restricted OLIG2-RTK signaling governs the molecular subtype of glioma stem-like cells

The bHLH transcription factor OLIG2 is a master regulator of oligodendroglial fate decisions and tumorigenic competence of glioma stem-like cells (GSCs). However, the molecular mechanisms underlying dysregulation of OLIG2 function during gliomagenesis remains poorly understood. Here, we show that OL...

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Publicat a:Cell Rep
Autors principals: Kupp, Robert, Shtayer, Lior, Tien, An-Chi, Szeto, Emily, Sanai, Nader, Rowitch, David H., Mehta, Shwetal
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5024710/
https://ncbi.nlm.nih.gov/pubmed/27626655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.08.040
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