Genetic impairments in folate enzymes increase dependence on dietary choline for phosphatidylcholine production at the expense of betaine synthesis

Although single nucleotide polymorphisms (SNPs) in folate-mediated pathways predict susceptibility to choline deficiency during severe choline deprivation, it is unknown if effects persist at recommended intakes. Thus, we used stable isotope liquid chromatography-mass spectrometry (LC-MS) methodolog...

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Veröffentlicht in:FASEB J
Hauptverfasser: Ganz, Ariel B., Shields, Kelsey, Fomin, Vlad G., Lopez, Yusnier S., Mohan, Sanjay, Lovesky, Jessica, Chuang, Jasmine C., Ganti, Anita, Carrier, Bradley, Yan, Jian, Taeswuan, Siraphat, Cohen, Vanessa V., Swersky, Camille C., Stover, Julie A., Vitiello, Gerardo A., Malysheva, Olga V., Mudrak, Erika, Caudill, Marie A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Federation of American Societies for Experimental Biology 2016
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5024689/
https://ncbi.nlm.nih.gov/pubmed/27342765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201500138RR
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