Holdase activity of secreted Hsp70 masks amyloid-β42 neurotoxicity in Drosophila

Alzheimer’s disease (AD) is the most prevalent of a large group of related proteinopathies for which there is currently no cure. Here, we used Drosophila to explore a strategy to block Aβ42 neurotoxicity through engineering of the Heat shock protein 70 (Hsp70), a chaperone that has demonstrated neur...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Fernandez-Funez, Pedro, Sanchez-Garcia, Jonatan, de Mena, Lorena, Zhang, Yan, Levites, Yona, Khare, Swati, Golde, Todd E., Rincon-Limas, Diego E.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2016
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PNAS Plus
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5024614/
https://ncbi.nlm.nih.gov/pubmed/27531960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1608045113
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