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Enhancement of hERG channel activity by scFv antibody fragments targeted to the PAS domain
The human human ether-à-go-go–related gene (hERG) potassium channel plays a critical role in the repolarization of the cardiac action potential. Changes in hERG channel function underlie long QT syndrome (LQTS) and are associated with cardiac arrhythmias and sudden death. A striking feature of this...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5024597/ https://ncbi.nlm.nih.gov/pubmed/27516548 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1601116113 |
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