Enhancement of hERG channel activity by scFv antibody fragments targeted to the PAS domain

The human human ether-à-go-go–related gene (hERG) potassium channel plays a critical role in the repolarization of the cardiac action potential. Changes in hERG channel function underlie long QT syndrome (LQTS) and are associated with cardiac arrhythmias and sudden death. A striking feature of this...

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Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Harley, Carol A., Starek, Greg, Jones, David K., Fernandes, Andreia S., Robertson, Gail A., Morais-Cabral, João H.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2016
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5024597/
https://ncbi.nlm.nih.gov/pubmed/27516548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1601116113
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