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Safety, tolerability, and pharmacokinetics of SMT C1100, a 2‐arylbenzoxazole utrophin modulator, following single‐ and multiple‐dose administration to healthy male adult volunteers

SMT C1100 is a small molecule utrophin modulator in development to treat Duchenne muscular dystrophy. This study evaluated the safety, tolerability, and pharmacokinetics of SMT C1100 in healthy volunteers. This double‐blind, placebo‐controlled Phase 1 study comprised: Part 1, an escalating, single‐d...

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Detaylı Bibliyografya
Yayımlandı:J Clin Pharmacol
Asıl Yazarlar: Tinsley, Jon, Robinson, Neil, Davies, Kay E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2015
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5024067/
https://ncbi.nlm.nih.gov/pubmed/25651188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.468
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