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High cell-surface density of HER2 deforms cell membranes

Breast cancers (BC) with HER2 overexpression (referred to as HER2 positive) progress more aggressively than those with normal expression. Targeted therapies against HER2 can successfully delay the progression of HER2-positive BC, but details of how this overexpression drives the disease are not full...

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Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Chung, Inhee, Reichelt, Mike, Shao, Lily, Akita, Robert W., Koeppen, Hartmut, Rangell, Linda, Schaefer, Gabriele, Mellman, Ira, Sliwkowski, Mark X.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5023959/
https://ncbi.nlm.nih.gov/pubmed/27599456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12742
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