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Reorienting the Fab Domains of Trastuzumab Results in Potent HER2 Activators
The structure of the Fab region of antibodies is critical to their function. By introducing single cysteine substitutions into various positions of the heavy and light chains of the Fab region of trastuzumab, a potent antagonist of HER2, and using thiol chemistry to link the different Fabs together,...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3527469/ https://ncbi.nlm.nih.gov/pubmed/23284778 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0051817 |
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