Iron Uptake via DMT1 Integrates Cell Cycle with JAK-STAT3 Signaling to Promote Colorectal Tumorigenesis

Dietary iron intake and systemic iron balance are implicated in colorectal cancer (CRC) development, but the means by which iron contributes to CRC are unclear. Gene expression and functional studies demonstrated that the cellular iron importer, divalent metal transporter 1 (DMT1), is highly express...

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Udgivet i:Cell Metab
Main Authors: Xue, Xiang, Ramakrishnan, Sadeesh K., Weisz, Kevin, Triner, Daniel, Xie, Liwei, Attili, Durga, Pant, Asha, Győrffy, Balázs, Zhan, Mingkun, Carter-Su, Christin, Hardiman, Karin M., Wang, Thomas D., Dame, Michael K., Varani, James, Brenner, Dean, Fearon, Eric R., Shah, Yatrik M.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5023486/
https://ncbi.nlm.nih.gov/pubmed/27546461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2016.07.015
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