Poly(ester amine) Composed of Polyethylenimine and Pluronic Enhance Delivery of Antisense Oligonucleotides In Vitro and in Dystrophic mdx Mice

A series of poly(esteramine)s (PEAs) constructed from low molecular weight polyethyleneimine (LPEI) and Pluronic were evaluated for the delivery of antisense oligonuclotides (AOs), 2′-O-methyl phosphorothioate RNA (2′-OMePS) and phosphorodiamidate morpholino oligomer (PMO) in cell culture and dystro...

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Veröffentlicht in:Mol Ther Nucleic Acids
Hauptverfasser: Wang, Mingxing, Wu, Bo, Tucker, Jason D, Bollinger, Lauren E, Lu, Peijuan, Lu, Qilong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5023397/
https://ncbi.nlm.nih.gov/pubmed/27483024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2016.51
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