Neural Stem Cells Engineered to Express Three Therapeutic Factors Mediate Recovery from Chronic Stage CNS Autoimmunity

Treatment of chronic neurodegenerative diseases such as multiple sclerosis (MS) remains a major challenge. Here we genetically engineer neural stem cells (NSCs) to produce a triply therapeutic cocktail comprising IL-10, NT-3, and LINGO-1-Fc, thus simultaneously targeting all mechanisms underlie chro...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Li, Xing, Zhang, Yuan, Yan, Yaping, Ciric, Bogoljub, Ma, Cun-Gen, Gran, Bruno, Curtis, Mark, Rostami, Abdolmohamad, Zhang, Guang-Xian
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5023377/
https://ncbi.nlm.nih.gov/pubmed/27203442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2016.104
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