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The leukemic oncoprotein NPM1-RARA inhibits TP53 activity
The variant acute promyelocytic leukemia (APL) translocation t(5;17)(q35;q21) fuses the N-terminus of nucleophosmin (NPM1) to the retinoic acid receptor alpha (RARA). We found that ectopic NPM1-RARA expression decreased TP53 protein levels in target cells. NPM1-RARA impaired TP53-dependent transcrip...
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| Publicado no: | Leuk Lymphoma |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5023140/ https://ncbi.nlm.nih.gov/pubmed/26754533 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/10428194.2015.1124992 |
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