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NPM-RAR binding to TRADD selectively inhibits caspase activation, while allowing activation of NFκB and JNK
The t(5;17) variant of acute promeylocytic leukemia (APL) expresses a fusion of nucleophosmin (NPM) with the retinoic acid receptor alpha (RARA). We have previously shown that NPM-RAR is a binding partner of the tumor necrosis factor receptor type-I –associated DEATH domain protein TRADD. Binding of...
Tallennettuna:
| Julkaisussa: | Leuk Lymphoma |
|---|---|
| Päätekijät: | , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2015
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4743255/ https://ncbi.nlm.nih.gov/pubmed/25791120 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/10428194.2015.1023799 |
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