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A novel phosphorylation site at Ser(130) adjacent to the pseudosubstrate domain contributes to the activation of protein kinase C-δ

Protein kinase C-δ (PKCδ) is a signalling kinase that regulates many cellular responses. Although most studies focus on allosteric mechanisms that activate PKCδ at membranes, PKCδ also is controlled via multi-site phosphorylation [Gong et al. (2015) Mol. Cell. Biol. 35, 1727–1740]. The present study...

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Detalhes bibliográficos
Publicado no:Biochem J
Main Authors: Gong, Jianli, Holewinski, Ronald J., Van Eyk, Jennifer E., Steinberg, Susan F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5022567/
https://ncbi.nlm.nih.gov/pubmed/26546672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20150812
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