α-Mangostin-encapsulated PLGA nanoparticles inhibit pancreatic carcinogenesis by targeting cancer stem cells in human, and transgenic (Kras(G12D), and Kras(G12D)/tp53R270H) mice

Activation of sonic hedgehog (Shh) in cancer stem cell (CSC) has been demonstrated with aggressiveness of pancreatic cancer. In order to enhance the biological activity of α-mangostin, we formulated mangostin-encapsulated PLGA nanoparticles (Mang-NPs) and examined the molecular mechanisms by which t...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Verma, Raj Kumar, Yu, Wei, Shrivastava, Anju, Shankar, Sharmila, Srivastava, Rakesh K.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5021984/
https://ncbi.nlm.nih.gov/pubmed/27624879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep32743
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