Differences in gynecologic tumor development in Amhr2-Cre mice with KRAS(G12D) or KRAS(G12V) mutations

How different KRAS variants impact tumor initiation and progression in vivo has not been thoroughly examined. We hypothesize that the ability of either KRAS(G12D) or KRAS(G12V) mutations to initiate tumor formation is context dependent. Amhr2-Cre mice express Cre recombinase in tissues that develop...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Kun, Eucharist H. S., Tsang, Yvonne T. M., Lin, Sophia, Pan, Sophia, Medapalli, Tejas, Malpica, Anais, Richards, JoAnne S., Gershenson, David M., Wong, Kwong-Kwok
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7693266/
https://ncbi.nlm.nih.gov/pubmed/33244099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-77666-y
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