A sliding-bulge structure at the Dicer processing site of pre-miRNAs regulates alternative Dicer processing to generate 5′-isomiRs

5′-isomiRs expand the repertoire of miRNA targets. However, how they are generated is not well understood. Previously, we showed that for some miRNAs in mammalian cells, Drosha cleaves at multiple sites to generate multiple pre-miRNAs that give rise to multiple 5′-isomiRs. Here, we showed that for s...

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Dettagli Bibliografici
Pubblicato in:Heliyon
Autori principali: Ma, Hongming, Wu, Yonggan, Niu, Qi, Zhang, Junli, Jia, Gengxiang, Manjunath, N., Wu, Haoquan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5021778/
https://ncbi.nlm.nih.gov/pubmed/27656682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.heliyon.2016.e00148
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