Application of the TGx‐28.65 transcriptomic biomarker to classify genotoxic and non‐genotoxic chemicals in human TK6 cells in the presence of rat liver S9

In vitro transcriptional signatures that predict toxicities can facilitate chemical screening. We previously developed a transcriptomic biomarker (known as TGx‐28.65) for classifying agents as genotoxic (DNA damaging) and non‐genotoxic in human lymphoblastoid TK6 cells. Because TK6 cells do not expr...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Environ Mol Mutagen
Prif Awduron: Yauk, Carole L., Buick, Julie K., Williams, Andrew, Swartz, Carol D., Recio, Leslie, Li, Heng‐Hong, Fornace, Albert J., Thomson, Errol M., Aubrecht, Jiri
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2016
Pynciau:
Research Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5021161/
https://ncbi.nlm.nih.gov/pubmed/26946220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/em.22004
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