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Macrocycle-Based Hydroxamate Ligands for Complexation and Immunoconjugation of (89)Zirconium for Positron Emission Tomography (PET) Imaging

Four novel chelators (L1–L4) and their (89)zirconium complexes were prepared and compared with the (89)zirconium desferrioxamine B (DFO) complex. The new chelates are based on 1,4,7,10-tetraazacyclododecane (cyclen) and 1,4,8,11-tetraazacyclotetradecane (cyclam) scaffolds and present either three or...

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Bibliographic Details
Published in:Chempluschem
Main Authors: Boros, Eszter, Holland, Jason P., Kenton, Nathaniel, Rotile, Nicholas, Caravan, Peter
Format: Artigo
Language:Inglês
Published: 2016
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5019580/
https://ncbi.nlm.nih.gov/pubmed/27630807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cplu.201600003
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