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Macrocycle-Based Hydroxamate Ligands for Complexation and Immunoconjugation of (89)Zirconium for Positron Emission Tomography (PET) Imaging

Four novel chelators (L1–L4) and their (89)zirconium complexes were prepared and compared with the (89)zirconium desferrioxamine B (DFO) complex. The new chelates are based on 1,4,7,10-tetraazacyclododecane (cyclen) and 1,4,8,11-tetraazacyclotetradecane (cyclam) scaffolds and present either three or...

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Detalhes bibliográficos
Publicado no:Chempluschem
Main Authors: Boros, Eszter, Holland, Jason P., Kenton, Nathaniel, Rotile, Nicholas, Caravan, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5019580/
https://ncbi.nlm.nih.gov/pubmed/27630807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cplu.201600003
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