The β-Secretase-Derived C-Terminal Fragment of βAPP, C99, But Not Aβ, Is a Key Contributor to Early Intraneuronal Lesions in Triple-Transgenic Mouse Hippocampus

Triple-transgenic mice (3xTgAD) overexpressing Swedish-mutated β-amyloid precursor protein (βAPP(swe)), P310L-Tau (Tau(P301L)), and physiological levels of M146V-presenilin-1 (PS1(M146V)) display extracellular amyloid-β peptides (Aβ) deposits and Tau tangles. More disputed is the observation that th...

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Gepubliceerd in:J Neurosci
Hoofdauteurs: Lauritzen, Inger, Pardossi-Piquard, Raphaëlle, Bauer, Charlotte, Brigham, Elizabeth, Abraham, Jean-Daniel, Ranaldi, Sébastien, Fraser, Paul, St-George-Hyslop, Peter, Le Thuc, Ophelia, Espin, Vanessa, Chami, Linda, Dunys, Julie, Checler, Frédéric
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Society for Neuroscience 2012
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Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5019353/
https://ncbi.nlm.nih.gov/pubmed/23152608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2775-12.2012
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