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Modifications of a Nanomolar Cyclic Peptide Antagonist for the EphA4 Receptor To Achieve High Plasma Stability
[Image: see text] EphA4 is a receptor tyrosine kinase with a critical role in repulsive axon guidance and synaptic function. However, aberrant EphA4 activity can inhibit neural repair after injury and exacerbate neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and Alzheimer’s....
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| Pubblicato in: | ACS Med Chem Lett |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Chemical
Society
2016
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5018863/ https://ncbi.nlm.nih.gov/pubmed/27660688 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00132 |
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